HIV Viral Dynamic under Treatment with Intracellular Delay and Virus Decay as Interactive Parameters

R. A. C. Prata, R. S. M. Jafelice, V. M. Cabral, F. S. Pedro, L. C. Barros


Treatment with antiviral drugs for human immunodeficiency virus type 1 (HIV-1) infection causes a rapid reduction in plasma viral load. Viral decline occurs in several stages and provides information on important kinetic constants of virus replication in vivo and pharmacodynamic properties. We present a mathematical model that not only considers the intracellular phase of the viral life cycle, defined as the time between the infection of a cell and the production of new viral particles, but we  also consider that this parameter together with the virus decay are interactive fuzzy numbers.


Joint possibility distribution; interactive fuzzy numbers; HIV model; Viral dynamics;

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Trends in Computational and Applied Mathematics

A publication of the Brazilian Society of Applied and Computational Mathematics (SBMAC)


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